| Peer-Reviewed

Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients

Received: 9 October 2015     Accepted: 21 October 2015     Published: 26 November 2015
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Abstract

The range of T cell abnormalities in advanced HIV-1 infection treatment is broad. The defects are both quantitative and qualitative and affect virtually every limb of the immune system. Beyond the precise measurement of naive T cells (CD45RA+CCR7+CD27+CD28+), the differential expression of different molecules on T cell allows the distinction between numerous subsets of resting or antigen-experienced T cells on the treatment. However, in spite of intense investigation, the mechanisms underlying highly active antiretroviral therapy (HAART) –induce immune reconstitution remain to be fully characterized. HAART treatment induced changes in the peripheral distribution of naïve (CD45RA+ CD62L+) and memory CD45RA- CD62L+) cells, CCR5, CXCR4-, CD95- expressing T cells, T-reg cells and on gamma delta (ϒδ) T cells. As a concluding remark prolonged suppression of plasma viral load ( pVL) by HAART improves not only ɑβ T-cell function but also ϒδ T-cell reactivity, and it is strongly recommended that once started the treatment, sever immunocompromized patient should continue the treatment for long time.

Published in International Journal of Immunology (Volume 3, Issue 6)
DOI 10.11648/j.iji.20150306.11
Page(s) 57-71
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

T-lymphocytes, HIV-1 Infection, Highly Active Antiretroviral Therapy

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    Addisu Gize Yeshanew, Afework Kassu Gizaw, Biniam Mathewos Tebeje. (2015). Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients. International Journal of Immunology, 3(6), 57-71. https://doi.org/10.11648/j.iji.20150306.11

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    ACS Style

    Addisu Gize Yeshanew; Afework Kassu Gizaw; Biniam Mathewos Tebeje. Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients. Int. J. Immunol. 2015, 3(6), 57-71. doi: 10.11648/j.iji.20150306.11

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    AMA Style

    Addisu Gize Yeshanew, Afework Kassu Gizaw, Biniam Mathewos Tebeje. Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients. Int J Immunol. 2015;3(6):57-71. doi: 10.11648/j.iji.20150306.11

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  • @article{10.11648/j.iji.20150306.11,
      author = {Addisu Gize Yeshanew and Afework Kassu Gizaw and Biniam Mathewos Tebeje},
      title = {Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients},
      journal = {International Journal of Immunology},
      volume = {3},
      number = {6},
      pages = {57-71},
      doi = {10.11648/j.iji.20150306.11},
      url = {https://doi.org/10.11648/j.iji.20150306.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20150306.11},
      abstract = {The range of T cell abnormalities in advanced HIV-1 infection treatment is broad. The defects are both quantitative and qualitative and affect virtually every limb of the immune system. Beyond the precise measurement of naive T cells (CD45RA+CCR7+CD27+CD28+), the differential expression of different molecules on T cell allows the distinction between numerous subsets of resting or antigen-experienced T cells on the treatment. However, in spite of intense investigation, the mechanisms underlying highly active antiretroviral therapy (HAART) –induce immune reconstitution remain to be fully characterized. HAART treatment induced changes in the peripheral distribution of naïve (CD45RA+ CD62L+) and memory CD45RA- CD62L+) cells, CCR5, CXCR4-, CD95- expressing T cells, T-reg cells and on gamma delta (ϒδ) T cells. As a concluding remark prolonged suppression of plasma viral load ( pVL) by HAART improves not only ɑβ T-cell function but also ϒδ T-cell reactivity, and it is strongly recommended that once started the treatment, sever immunocompromized patient should continue the treatment for long time.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Effect of Highly Active Antiretroviral Therapy on T-Cell Sub-population Profile in Human Immunodeficiency Virus-1 Infected Patients
    AU  - Addisu Gize Yeshanew
    AU  - Afework Kassu Gizaw
    AU  - Biniam Mathewos Tebeje
    Y1  - 2015/11/26
    PY  - 2015
    N1  - https://doi.org/10.11648/j.iji.20150306.11
    DO  - 10.11648/j.iji.20150306.11
    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
    SP  - 57
    EP  - 71
    PB  - Science Publishing Group
    SN  - 2329-1753
    UR  - https://doi.org/10.11648/j.iji.20150306.11
    AB  - The range of T cell abnormalities in advanced HIV-1 infection treatment is broad. The defects are both quantitative and qualitative and affect virtually every limb of the immune system. Beyond the precise measurement of naive T cells (CD45RA+CCR7+CD27+CD28+), the differential expression of different molecules on T cell allows the distinction between numerous subsets of resting or antigen-experienced T cells on the treatment. However, in spite of intense investigation, the mechanisms underlying highly active antiretroviral therapy (HAART) –induce immune reconstitution remain to be fully characterized. HAART treatment induced changes in the peripheral distribution of naïve (CD45RA+ CD62L+) and memory CD45RA- CD62L+) cells, CCR5, CXCR4-, CD95- expressing T cells, T-reg cells and on gamma delta (ϒδ) T cells. As a concluding remark prolonged suppression of plasma viral load ( pVL) by HAART improves not only ɑβ T-cell function but also ϒδ T-cell reactivity, and it is strongly recommended that once started the treatment, sever immunocompromized patient should continue the treatment for long time.
    VL  - 3
    IS  - 6
    ER  - 

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Author Information
  • Department of Microbiology, Immunology and Parasitology, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia

  • Department of Microbiology, Immunology and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

  • QIMR Berghofer Medical Research Institute, Brisbane, Australia

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