Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases:: Science Publishing Group

Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases

Adou Adjoumanvoule Honore¹, Siransy Kouabla Liliane¹, Memel Lasme Roselle Charline², Yeboah Oppong Richard¹, Goran-Kouacou Amah Patricia¹, Kone Djakaridja³, Kadiane N’Dri Juliette³, Assi Aya Ursule Aniela¹, Gnemagnon Mahi Eric Constant³, Ouattara Awa³, Oura Brou Doris¹, Moussa Sali¹, Koya Hebert Gautier², Seri Yida Jocelyne¹, Aba Yapo Thomas³, Krah Ouffoue³

¹Immunology-Allergology Department, Training Hospital of Cocody, Abidjan, Ivory Coast

²Immunology Department, Training Hospital of Bouake, Ivory Coast

³Infectious and Tropical Diseases Department, Training Hospital, Bouake, Ivory Coast

International Journal of Immunology, Volume 11, Issue 1, March 2023

Pages: 1-5

Received: Mar. 07, 2023

Accepted: Apr. 06, 2023

Published: May 10, 2023

DOI: 10.11648/j.iji.20231101.11

Downloads:

Views:

Download PDF: Download PDF

Export Citation: Export citation to RIS Export citation to BibTeX

Abstract

Introduction: Blood types are most often incriminated in susceptibility to COVID-19. Blood group O subjects are reportedly less susceptible to COVID-19. However, these reports are mainly from countries with high infection rates. The overall objective of this study was to investigate the association between the risk of COVID-19 infection, its severity, and ABO-RHD blood groups at the Training Hospitals of Bouake and Cocody (Ivory Coast). Material and methods: This was a prospective study that lasted four months. All patients with COVID-19 at the time of the study and followed at the Training Hospitals of Bouake and Cocody, hospitalized in the COVID-19 centers or in home confinement, were included. T lymphocyte subpopulations were counted on the BD FACS Calibur flow cytometer after labeling. ABO and RHD blood typing was performed in all patients. Results: Of the 76 patients collected, 78.9% were homebound, 18.4% in hospital and 2.6% in the ICU. The mean age was 41.92 ± 15.13 years with a male predominance. The majority of hospitalized patients were significantly of blood group A (p=0.020). CD4 and CD8 T lymphopenia were significantly more frequent in patients with blood group A than in those with blood groups B, AB and O. Conclusion: The impact of blood group on the severity of the disease would exist. Our study showed that blood group A subjects were more likely to have COVID-19. In addition, a statistically significant association between blood type A and CD4 and CD8 T lymphopenia was found. These results should be confirmed by studies based on larger patient samples.

Keywords

Lymphopenia, CD4, CD8, COVID-19, ABO-RHD Blood Groups

To cite this article

Adou Adjoumanvoule Honore, Siransy Kouabla Liliane, Memel Lasme Roselle Charline, Yeboah Oppong Richard, Goran-Kouacou Amah Patricia, et al. (2023). Association Between ABO-RHD Blood Groups and COVID-19: A Preliminary Study of 76 Cases. International Journal of Immunology, 11(1), 1-5. https://doi.org/10.11648/j.iji.20231101.11

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

1.	Abdelmalek R. COVID-19, chroniques d’une pandémie annoncée COVID-19, chronicles of a forecasted pandemic.: 4.
2.	Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis Off Publ Infect Dis Soc Am. 28 juill 2020; 71 (15): 762-8.
3.	Zhou X, Ye Q. Cellular Immune Response to COVID-19 and Potential Immune Modulators. Front Immunol [Internet]. 2021 [cité 20 janv 2022]; 12. Disponible sur: https://www.frontiersin.org/article/10.3389/fimmu.2021.646333
4.	Planté-Bordeneuve T, Froidure A, Pilette C. Immunité et COVID-19 : état des lieux, vers une médecine de précision ?: 7.
5.	Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Deng Y, et al. Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis. Int J Infect Dis. juill 2020; 96: 131-5.
6.	Huang W, Berube J, McNamara M, Saksena S, Hartman M, Arshad T, et al. Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis. Cytom Part J Int Soc Anal Cytol. août 2020; 97 (8): 772-6.
7.	Goel R, Bloch EM, Pirenne F, Al-Riyami AZ, Crowe E, Dau L, et al. ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 Working Group. Vox Sang. 2021; 116 (8): 849-61.
8.	Bourhanbour AD, Bakkouri JE. CONNAISSANCES ACTUELLES DE L’IMMUNOPATHOLOGIE DU COVID-19. Rev Marocaine Santé Publique [Internet]. 18 mai 2020 [cité 20 janv 2022]; 7 (10). Disponible sur: https://revues.imist.ma/index.php/RMSP/article/view/20927
9.	Liu N, Zhang T, Ma L, Zhang H, Wang H, Wei W, et al. The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis. Blood Rev. juill 2021; 48: 100785.
10.	Hardy ÉJL, Flori P. Spécificités épidémiologiques de la COVID-19 en Afrique: préoccupation de santé publique actuelle ou future ? Ann Pharm Fr. 1 mars 2021; 79 (2): 216-26.
11.	Dosi R, Jain G, Mehta A. Clinical Characteristics, Comorbidities, and Outcome among 365 Patients of Coronavirus Disease 2019 at a Tertiary Care Centre in Central India. J Assoc Physicians India. 1 sept 2020; 68 (9): 20-3.
12.	Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet Lond Engl. 15 févr 2020; 395 (10223): 497-506.
13.	Donamou J, Bangoura A, Camara LM, Camara D, Traoré DA, Abékan RJM, et al. Caractéristiques épidémiologiques et cliniques des patients COVID-19 admis en réanimation à l’hôpital Donka de Conakry, Guinée: étude descriptive des 140 premiers cas hospitalisés. Anesth Réanimation. 1 mars 2021; 7 (2): 102-9.
14.	Eboko F, Schlimmer S. COVID-19: l’Afrique face à une crise mondiale. Polit Étrangère. 2020; Hiver (4): 123-34.
15.	COVID-19: quelles classes d’âge portent la reprise épidémique? [Internet]. BFMTV. [cité 5 mars 2022]. Disponible sur: https://www.bfmtv.com/sante/COVID-19-quelles-classes-d-age-portent-la-reprise-epidemique_AV-202111120148.html
16.	Masson E. Études preliminaires : caractéristiques épidémiologiques, cliniques et radiologiques des patients atteints de pneumonie à SARS-CoV2 au service de pneumo-phtisiologie du CHU Treichville [Internet]. EM-Consulte. [cité 19 janv 2022]. Disponible sur: https://www.em-consulte.com/article/1419490/etudes-preliminaires-caracteristiques-epidemiolog
17.	Moueden MA, Benlaldj D, Messaoudi R, Seghier F. Profil hématologique des patients atteints de COVID 19 au niveau du CHU d’Oran en Algérie. Algerian J Health Sci. 30 mars 2021; 3 (2): 22-9.
18.	COVID-19: le système immunitaire des femmes est-il plus robuste que celui des hommes? BBC News Afrique [Internet]. [cité 19 janv 2022]; Disponible sur: https://www.bbc.com/afrique/monde-54526559
19.	Dimassi I, Mahjoub S, Cherni R, Baccouche H, Chakroun A, Ben Romdhane N. Groupe sanguin ABO et sévérité de la COVID-19: étude monocentrique. Transfus Clin Biol. 1 nov 2021; 28 (4, Supplement): S115-6.
20.	Kibler M, Dietrich L, Kanso M, Carmona A, Marchandot B, Matsushita K, et al. Risk and Severity of COVID-19 and ABO Blood Group in Transcatheter Aortic Valve Patients. J Clin Med. 22 nov 2020; 9 (11): 3769.
21.	Li J, Wang X, Chen J, Cai Y, Deng A, Yang M. Association between ABO blood groups and risk of SARS-CoV-2 pneumonia. Br J Haematol. 26 mai 2020; 10.1111/bjh.16797.
22.	Ray JG, Schull MJ, Vermeulen MJ, Park AL. Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness : A Population-Based Cohort Study. Ann Intern Med. mars 2021; 174 (3): 308-15.